The mononuclear cell (MNC) fraction contains the MSC. In vitro, these cells give rise to fibroblast colony-forming units (CFU-F) capable of undergoing osteogenesis, chondrogenesis and adipogenesis when cultured in their respective specific induction medium1.
BMC are used alone3, 8, or in combination with bone grafts or synthetic osteoconductive scaffolds4-8.
BMC can also be combined with platelet-rich plasma (RegenPRP) and autologous thrombin serum (ATS) prepared with RegenKit® Surgery to obtain a gel.
BMC prepared with RegenKit® Extracell® from a small volume of bone marrow aspirate (max 40 ml) have been used successfully for complex bone healing problems such as:
Complete healing was obtained for around 80% of the lesions1-8
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